Genome Wide Association Study Identifies Genetic Variants Associated With Early And Sustained Response To (Peg)Interferon In Chronic Hepatitis B Patients: The GIANT-B Study

Willem P. Brouwer,Henry Lik-Yuen Chan,Pietro Lampertico,Jinlin Hou,Pisit Tangkijvanich,Hendrik W. Reesink,Wenhong Zhang,Alessandra Mangia,Tawesak Tanwandee,Giuseppe Montalto,Kris Simon,Necati Örmeci,Liang Chen,Fehmi Tabak,Fulya Gunsar,Robert Flisiak,Peter Ferenci,Meral Akdoğan,Filiz Akyuz,Nattiya Hirankarn,Louis Jansen,Vincent Wai-Sun Wong,Roberta Soffredini,Xieer Liang,Shalom Chen,Zwier M. A. Groothuismink,Rosanna Santoro,Jerzy Jaroszewicz,Reşat Özaras,K Kozbial,Mayur Brahmania,Qing Xie,Watcharasak Chotiyaputta,Qi-xun,Monika Pazgan-Simon,Erkin Öztaş,Elke Verhey,Noé R Montanari,Jian Sun,Bettina E. Hansen,Andre Boonstra,Harry L.A. Janssen,Willem Pieter Brouwer,Bettina Hansen,Harry L.A. Janssen,Heng Chi,Milan J. Sonneveld,Noe Rico Montanari,Rob de Knegt,Henry Chan,Vincent Wai-Sun Wong,Grace Lai-Hung Wong,Marta Borghi,Alessandro Loglio,Pimpayao Sodsai,Natthaya Chuaypen,Henk Reesink,Guiseppe Montalto,Xi Qun,Jordan J Feld,Seham Noureldin,Simin Guo

Genome Wide Association Study Identifies Genetic Variants Associated With Early And Sustained Response To (Peg)Interferon In Chronic Hepatitis B Patients: The GIANT-B Study

2019

Willem P. Brouwer
Henry Lik-Yuen Chan
Pietro Lampertico
Jinlin Hou
Pisit Tangkijvanich
Hendrik W. Reesink
Wenhong Zhang
Alessandra Mangia
Tawesak Tanwandee
Giuseppe Montalto
Kris Simon
Necati Örmeci
Liang Chen
Fehmi Tabak
Fulya Gunsar
Robert Flisiak
Peter Ferenci
Meral Akdoğan
Filiz Akyuz
Nattiya Hirankarn
Louis Jansen
Vincent Wai-Sun Wong
Roberta Soffredini
Xieer Liang
Shalom Chen
Zwier M. A. Groothuismink
Rosanna Santoro
Jerzy Jaroszewicz
Reşat Özaras
K Kozbial
Mayur Brahmania
Qing Xie
Watcharasak Chotiyaputta
Qi-xun
Monika Pazgan-Simon
Erkin Öztaş
Elke Verhey
Noé R Montanari
Jian Sun
Bettina E. Hansen
Andre Boonstra
Harry L.A. Janssen
Willem Pieter Brouwer
Bettina Hansen
Harry L.A. Janssen
Heng Chi
Milan J. Sonneveld
Noe Rico Montanari
Rob de Knegt
Henry Chan
Vincent Wai-Sun Wong
Grace Lai-Hung Wong
Marta Borghi
Alessandro Loglio
Pimpayao Sodsai
Natthaya Chuaypen
Henk Reesink
Guiseppe Montalto
Xi Qun
Jordan J Feld
Seham Noureldin
Simin Guo

Background (Pegylated) Interferon ([Peg]IFN) therapy leads to response in a minority of chronic hepatitis B (CHB) patients. Host genetic determinants of response are therefore in demand.

Keywords:

Hepatitis B
Virology
Immunology
PEG ratio
Genome-wide association study
Interferon
Medicine
Hepatitis B virus
HBeAg
Pegylated interferon
Interleukin
HBsAg
Peripheral blood mononuclear cell

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