Charge Density Distribution of Dimethyl-1,3-Amino-4-Uracil

In the field of research aimed at providing new antitumor drugs we have worked on 5-acyl-6-amino-1,3-dimethyluracils. Among these compounds, 6-amino-5-cinnamoyl-1,3- dimethyluracil (NSC 290115) has revealed interesting antileukaemia activity. The aromatic groups are stabilized in an extended planar structure whose size fits with the base planes of the DNA.