Photodynamic Therapy with Verteporfin for Symptomatic Circumscribed Choroidal Hemangioma: Five-Year Outcomes

Objective To evaluate the long-term efficacy of verteporfin photodynamic therapy (PDT) as the primary treatment for symptomatic circumscribed choroidal hemangioma (CCH). Design Prospective consecutive, 2-centered, noncomparative, interventional case series. Participants Twenty-five subjects with symptomatic CCH. All patients had recent onset of visual symptoms and evidence of exudative macular changes on fluorescein angiography (FA) and optical coherence tomography (OCT). Methods Verteporfin 6 mg/m 2 body surface area was administered intravenously over a 10-minute interval. Five minutes after infusion, a 689 nm laser was applied with a light dose of 50 J/cm 2 for the first 3 patients and a light dose of 100 J/cm 2 for all the other patients. Retreatments were performed in case of persistent exudation found on OCT. Evaluation of best-corrected visual acuity (BCVA) using Early Treatment of Diabetic Retinopathy Study (ETDRS) criteria, FA, indocyanine green angiography (ICGA), OCT, and ultrasound were performed before PDT and on follow-up examinations. All patients were followed for at least 5 years. Main Outcome Measures Primary outcome measures were changes in BCVA and foveal center thickness (FCT) between baseline and month 60. Secondary measures were tumor thickness decrease, absence of leakage on FA, and adverse events. Results Twenty-two patients received 1 PDT session at 100 J/cm 2 , and no recurrences were detected. Three eyes, treated with 50 J/cm 2 , received a second PDT session at 100 J/cm 2 1 month after the first session. After a follow-up of 60 months, BCVA improved an average of 18.5 ETDRS letters ( P Conclusions The 5-year results of PDT in treating symptomatic CCH support treatment with a light dose of 100 J/cm 2 after slow intravenous infusion of verteporfin to stabilize or improve visual acuity and resolution of macular exudation. Financial Disclosure(s) The authors have no proprietary or commercial interest in any materials discussed in this article.