ER transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, Cellular Adherence and Embryonic Gastrulation

Here we characterize TMTC3 as an ER, polytopic membrane protein with C-terminal luminal-facing TPRs, and an O-mannosyltransferase of E-cadherin. O-mannosylation of cadherins by TMTC3 affects cellul...