Drug and food for the brain dysfunction prevention and improvement

The present invention provides a means for improving the symptoms of brain dysfunction. The present invention shall, when administered sepiapterin from peripheral, activity of brain aromatic monoamine is found in a new increase. Therefore, provided sepiapterin or a medicament for prophylactic or ameliorating at least containing brain dysfunction and its salts, and, sepiapterin or prophylactic or food for amelioration of at least the contained was brain dysfunction salt thereof . Sepiapterin, unlike such tetrahydrobiopterin, be peripherally administered to suppress intracerebral aromatic monoamines (serotonin, dopamine, noradrenaline, etc.) cranial nerve intracellular levels decrease, it is possible to increase the activity of. Therefore, brain dysfunction due to brain neuronal levels decrease in brain aromatic monoamines, for example, depression, bulimia, autism, consciousness concentration disorders, central psychiatric disorders such as cognitive disorders, and muscle tone, rigidity, vibration there is a possibility of war is effective in such central movement disorders, such as.