Research Progress on Immunology of Conjugate Linoleic Acid

The conjugate linoleic acid is one kind conjugate polyene which including many kinds of the spatial and positions isomer that always derivation from the vaccenic acid,only the isomer such as"c9,t11"、 "t10,c12"、 "t9,t11"and "t10,t12" has the strong biology function.The aspect of the immunology research indicated that,they can increase the content of IgG,IgA and IgM and reduces the IgE level in the circumference blood and mesentery lymphatic node;Increases the mitosis original,promotes the T and B lymphocyte multiplication regulation;Enhances the function which T-cell CD~+ special effect knows how to deal with and lymphocyte cell toxicity;The activation macrophage expresses abilities of the cell factor including iNOS-mRNA,IL-1,IL-6,IL-4 and TNF-α,and then participates in organism immune system control action.The regulative mechanism can alleviate the expression of animal immunity stress function,it is possible concerned with activation macrophage nucleus duplication factor—the response element of peroxidase proliferation activation receptor-gamma(PPAR-γ),reduces the mRNA expression which induced the inflammatory medium by γ-interferon.