WELL-DEVELOPED NANOSTRUCTURE INCORPORATED WITH Euphorbia umbellata EXTRACT INTO A UNIQUE FORM WITH GREATER BIOCOMPATIBILITY

The study demonstrated a combination of Polysaccharide-Based Nanoparticles with Euphorbia umbellata (Pax) Bruyns extract, Euphorbiaceae, into a unique form. The composite nanoparticles were prepared by using two biocompatible polymers, alginate (ALG) and chitosan (CS), by ionotropic pre-gelation followed by polycationic cross-linking. Nanoformulations were studied aiming future applications of this new material as medicine. In order to investigate potential interactions between ALG/CS and the extract, physicochemical characterization was performed by transmission electron microscopy (TEM), scanning electron microscopy (SEM), particle size and zeta potential, Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). The release profiles of phenolic compounds from loaded alginate/chitosan nanoparticles (ALG/CS-NPs) were evaluated using quantification method.The changes can be attributed to chemical interactions that occurred between the structure of the ALG/CS and the phenolic compounds present in the studied extract.