Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2

Jia Wang,Peng Cheng,Marat S. Pavlyukov,Hai Yu,Zhuo Zhang,Sung Hak Kim,Mutsuko Minata,Ahmed Mohyeldin,Wanfu Xie,Dongquan Chen,Violaine Goidts,Brendan Frett,Wenhao Hu,Hong Yu Li,Yong Jae Shin,Yeri Lee,Do Hyun Nam,Harley I. Kornblum,Maode Wang,Ichiro Nakano

Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2

2017

NIH [P01CA163205, R01NS083767, R21CA175875, R01NS087913, R01CA183991, 3T32GM008804-10S1, 5T32GM008804-10]; First Affiliated Hospital of Xi'an Jiaotong University; China Scholar Council; Russian Foundation for Basic Research [16-04-01209]; Russian Federation; Korea Health Technology RD Ministry of Health & Welfare, Republic of Korea [HI14C3418]

Keywords:

Christian ministry
Alternative medicine
Glioblastoma
Radioresistance
Health technology
EZH2
Welfare
Histone methyltransferase
Medicine
Glioma
Kinase
Biochemistry
Binding protein
protein degradation
Stem cell
Cancer research

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