2,2,6,6-四甲基-4-氨基哌啶的精馏提纯

The saturated vapor pressures of 4-amino-2,2,6,6-tetramethyl-4-piperidine and 2,2,6,6-tetramethyl-4-hydroxypiperidine were predicted by CSGC-PRV equation, and the Antoine equations for the two components were correlated. The activity coefficients of the components in the binary mixture of 4-amino-2,2,6,6-tetramethyl-4-piperidine and 2,2,6,6-tetramethyl-4-hydroxypiperidine were calculated by COSMO-SAC method. The Vapor-Liquid Equilibrium (VLE) data of the binary system were obtained by bubble point calculation. Based on the calculation results, 4-amino-2,2,6,6-tetramethyl-4-piperidine was purified by batch distillation from the binary mixture, and the purity of the obtained product was greater than 99.00%.