Association of ADAM33 gene polymorphisms with COPD in tibetan population of China

Objective Chronic obstructive pulmonary disease(COPD) is a common,complex disorder associated with substantial morbidity and mortality,influenced by both environmental and genetic factors.ADAM33 gene was found tobe associated with asthma,declined lung function and COPD.The purpose of the study was to test whether SNPs in ADAM33 were associated with COPD in Tibetan population of China. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was carried out to genotype the 4 SNPs(T2,T1,S2,S1)of ADAM33 on 240 COPD patients and 221 healthy individuals. Results 3 SNPs(T2,T1 and S1) were associated with COPD significantly (defined as P< 0.05). Conclusions The results indicating an association between ADAM33 polymorphisms and COPD in Tibetan population of China. Key words: A disintegrin and metallopro-teinase domain 33; Single nucleotide polymorphism; Chronic obstructive pulmonary disease; Haplotype; Chinese Tibetans