Doxorubicin-loaded biodegradable chitosan–graphene nanosheets for drug delivery applications

Nanocomposites and nanomaterials have frequently useful advantages for drug delivery applications because of their excellent potential in cancer therapy. This study development of nanocomposites from graphene/N-phthaloylchitosan –graft- poly(methylmethacrylate-block-(poly ethylenglycol methacrylate -random-dimethylaminoethyl methacrylate), CS-g-P(MMA-b-(PEGMA-ran-DMAEMA), via reversible addition fragmentation chain transfer polymerization. The structure of the copolymer and nanocomposite were investigated by FT-IR and 1HNMR. The nanocomposites properties of GO/ CS-g-P(MMA-b-(PEGMA-ran-DMAEMA) were investigated by scanning electron microscopy (FE-SEM), dynamic light scattering, ultraviolet–visible (UV–Vis) spectroscopies, and thermogravimetry measurements. We developed a biodegradable GO nanocomposites to overcome limitations of doxorubicin (DOX)-loading. The drug loading efficiency of GO/nanocomposites for DOX was high, and 81% efficiency was obtained. Release behavior of DOX from the nanocomposites showed that the rate of DOX release is controlled by pH values.