Inactivation of stem cells by allogeneic lymphocytes: competition between T1 and T2 subpopulations

Transplatation of bone marrow cells mixed with allogeneic T lymphocytes into irradiated recipients is accompanied by inactivation of stem cells of the graft. Lymphocytes from lymph nodes of T mice possess greater inactivating power than T lymphocytes from the spleen. In the case of the combined action of T lymphocytes from the spleen and T lymphocytes from the lymph nodes, inactivation of the stem cells was slight in degree or absent altogether.