Benefit of a low-fat over high-fat diet on vascular health during alternate day fasting

RESULTS: Body weight was reduced (Po0.0001) in the ADF-HF (4.4±1.0 kg) and ADF-LF group (3.7±0.7 kg). FMD decreased (Po0.05) by ADF-HF relative to baseline (7± 1t o 5±2%) and increased (Po0.05) by ADF-LF (5± 1t o 7±2%). Blood pressure remained unchanged in both groups. Adiponectin increased (Po0.05) in the ADF-HF (43±7%) and ADF-LF group (51±7%). Leptin and resistin decreased (Po0.05) in the ADF-HF (32±5%; 23±5%) and ADF-LF group (30±3%; 27±4%). Increases in adiponectin were associated with augmented FMD in the ADF-LF group only (r ¼ 0.34, P ¼ 0.03). CONCLUSION: Thus, improvements in FMD with ADF may only occur with LF diets and not with HF diets, and adipokines may not have a significant role in mediating this effect.