Transverse mode analysis of optofluidic intracavity spectroscopy of canine hemangiosarcoma
2010
The label-free technique of optofluidic intracavity spectroscopy (OFIS) uses the optical transmission spectrum of a cell
in a microfluidic optical resonator to distinguish cancerous and non-cancerous cells. Based on their distinctive
characteristic transmission spectra, canine hemangiosarcoma (HSA) cancer cells and normal peripheral blood
mononuclear cells (PBMCs) have been differentiated using the OFIS technique with high statistical significance (p -
6 ). 95% sensitivity and 98% specificity were achieved simultaneously. A cell lens model explains trends in the transverse
mode pattern in the transmission spectra of HSA cells and allows extraction of cell focal length.
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