Role of RGD in Integrin and Fibronecin Mediated Biological Process

Integrin directly participate in the control of cellular differentiation,morphogenesis,proliferation,and migrationin in Cell-matrix interactions,Many of these interactions with the extracellular matrix are mediated by the integrin family of cell adhesion molecules.In addition to their adhesive function,integrin receptor function can be regarded as a key modulator of cellular behaviour[1].Among the many molecules that are selectively expressed inangiogenic vasculature,the integrins show particular promise in tumor targeting.Saiki and co-worlers reported that tumor angiogenins can be inhibited by the interaction between integrins and the RGD(Arg-Gly-Asp) motif-containing extra cellular matrix proteins[2].One of the most studied target epitopes on angiogenic neovasculature is the αvβ3 and αvβ integrins are upregulated in angiogenic endothelial cells[3] and the inhibition of these integrins by antibodies,cyclic RGD peptides[4] and RGD peptidomimetics can block neovascularization.this review is to outline what is the role of RGD in integrin and fibronecin mediated biological process.