Trace Analysis of Anions in Perfluorodecalin by Green Liquid–Liquid Extraction Combined with Ion Chromatography

Perfluoronaphthenes, with inert chemical and biological properties and ability to dissolve large amounts of oxygen, have received the most attention in medical applications. However, the excessive anion contained may cause some side effects. Herein, liquid–liquid extraction technique with shaking and ultrasonic extraction was used for the trace analysis of five anions (F−, Cl−, NO3−, PO43−, SO42−) in perfluorodecalin using water as green extractant. The optimum pretreatment technology and ion chromatography detection conditions were established. Good linearity was observed in each concentration range, and the linear correlation coefficient (R2) was better than 0.997. The limits of detection (S/N = 3) of five anions from perfluorodecalin were 3.2, 5.5, 14.2, 23.2 and 29.5 μg/L, respectively. The established method with high sensitivity and accuracy has been successfully appliedfor the determination of five anions in three perfluorodecalin products, which provides a basis for further development of green detection and quality standard formulation in perfluorodecalin and other fluorocarbon solvents.