Relations between resistin and hepatic fibrosis in nonalcoholic fatty liver disease subjects

Objective To evaluate the relationship between resistin and hepatic fibrosis in nonalcoholic fatty liver disease （NAFLD） subjects.Methods Serum resitin and Interleukin （IL）-18’s concentrations were measured in 144 subjects （70 NAFLD pa-tients and 74 healthy controls） with enzyme-linked immunosorbent assay （ELISA） and their serum alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, fasting blood glucose （FBG）, HbA1c, triglyceride （TG）, total-cholesterol （TC）, low density lip-oprotein （ LDL） , high density lipoprotein （ HDL） , homeostasis model assessment of insulin resistance （ HOMA-IR） , hyaluronic acid , IVcollagen, height, body weight, waist circumference, and hip circumference were also measured .Their waist-to-hip ratio （WHR） and body mass indes （BMI） were calculated.Results There were higher levels of systolic blood pressure （SBP）, WHR, BMI, TG, ALT, AST, HOMA-IR, hyaluronic acid, IV collagen, resistin, and IL-18 in the NAFLD patients than those of the healthy controls （ P <0.05 ） .The serum resistin level was significantly and positively correlated with WHR , BMI, ALT, HOMA-IR, TG, IV collagen , and IL-18 （ r =0.231 , 0.341 , 0.223 , 0.264 , 0.213 , 0.315 , and 0.669 , P <0.05 ） .After adjustment for body fat and IL-18 , the serum resistin level was still significantly and positively correlated with ALT and IV collagen （ r =0.222 , 0.0.326 , P <0.05 ） . Conclusions Resistin might take part in the development of NAFLD insulin resistance and its pro -inflammation. Key words: Fatty liver/metabolism; Resistin/blood; Insulin resistance; Liver cirrhosis