Quantum dots light emitting devices on MEMS - Microcontact printing, near-field imaging, and early cancer detection
2011
Controlled patterning of light emitting devices on semiconductors and micro-electro-mechanical systems (MEMS) enables
a vast variety of applications such as structured illumination, large-area flexible displays, integrated optoelectronic
systems and micro-total analysis systems for real-time biomedical screening. We have demonstrated a series of techniques
of creating quantum dot-based (QD) patterned inorganic light emitting devices at room temperature on silicon (Si)
substrate. The innovative technology was translated to create localized QD-based light sources for two applications: (1)
Three-dimensional scanning probe tip structures for near field imaging. Combined topographic and optical images were
acquired using this new class of "self-illuminating" probe in commercial NSOM. The emission wavelength can be tuned
through quantum-size effect of QDs. (2) Multispectral excitation sources integrated with microfluidic channels for tumor
cell analyses. We were able to detect the variation of sub-cellular features, such as the nucleus-to-cytoplasm ratio, to
quantify the absorption at different wavelength upon the near-field illumination of individual tumor cells towards the
determination of cancer developmental stage.
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