Bisphosphonate treatment of aggressive primary, recurrent and metastatic Giant Cell Tumour of Bone

Background Giant cell tumour of bone (GCTB) is an expansile osteolytic tumour which contains numerous osteoclast-like giant cells. GCTB frequently recurs and can produce metastatic lesions in the lungs. Bisphosphonates are anti-resorptive drugs which act mainly on osteoclasts.