The association between adipocytokines and glycemic control in women with gestational diabetes mellitus

Abstract Objective: To evaluate the relationship between adipocytokines and glycemic control. Study design: Prospective observational trial of gestations with gestational diabetes mellitus (GDM). Fasting glucose (FG), insulin, adiponectin, Leptin, chemerin, Retinol Binding Protein 4 (RBP-4), osteocalcin and resistin were measured. HomeOstasis model assessment of insulin resistance (HOMA-IR) and QUantitative insulin sensitivity ChecK Index (QUICKI) were calculated. Women who required medications for glycemic control were compared to women using nutritional therapy only. Results: Overall, 75 women were included −26 (34.7%) required medications to achieve good glycemic control. Factors associated with poor control: low resistin (aOR 0.84), HOMA-IR (aOR 1.96), QUICKI (aOR 0.62), first trimester FG (aOR 1.43) and maternal age (aOR 1.26). HOMA-IR and QUICKI performed highest for prediction. Resistin, first trimester FG, maternal age and QUICKI had an AUC of 0.878, sensitivity and specificity of 87.5% for the pr...