Evaluation of safety and efficacy of adipose-derived stem cells in rat myocardial infarction model using hexadecyl-4-[124I]iodobenzoate for cell tracking

Abstract This study was aimed to evaluate the effect of 124 I-labeling with hexadecyl-4-iodobenzoate (HIB) on gene expression related to cell cycle, DNA repair, transcription, proliferation and differentiation of adipose-derived stem cells (ADSCs). [ 124 I]HIB showed high labeling efficiency with ADSCs (51.3±1.3%, 0.3–2.0 Bq/cell) and there is no morphological change of ADSCs. In the microarray analysis of gene expression pattern, differences were not observed between non-labeled and [ 124 I]HIB-labeled ADSCs. We demonstrated that 124 I-labeling with HIB did not affect the biological properties of ADSCs.