Regression of peripapillary choroidal neovascularization after oscillatory transpupillary thermotherapy and anti-VEGF pharmacotherapy.

PurposeWe prospectively evaluated a new treatment for recalcitrant choroidal neovascularization (CNV) in 4 patients. We used an infrared laser (810 nm) in oscillatory thermotherapy (OTT) mode combined with indocyanine green (ICG) dye, utilizing the beneficial effect of both thermotherapy and photodynamic therapy We describe preliminary experiences with ICG-assisted OTT (I-OTT) combined with intravitreal bevacizumab/dexamethasone for refractory peripapillary CNV resistant to standard therapy.MethodsClinical examination, funduscopy fluorescein angiography, and optical coherence tomography were performed at baseline and postoperatively. Infrared laser spot size was approximately one-half the lesion size (oscillation 2–3 Hz). Intravitreal injections of bevacizumab (1.25 mg) and dexamethasone (1000 μg) were done during the same visit.ResultsMean follow-up was 12.5 months (range 5–17). Mean energy level was 325 mW (range 200–500) in oscillatory mode (2–3 Hz/sec) pre- and post-ICG infusion. Indocyanine green dos...