Novel role of PKR in palmitate-induced Sirt1 inactivation and endothelial cell senescence

Yapei Li,Zhouyangfan Peng,Chunle Wang,Le Li,Yiping Leng,Ruifang Chen,Hong Yuan,Shenghua Zhou,Zhen Zhang,Alex F. Chen

Novel role of PKR in palmitate-induced Sirt1 inactivation and endothelial cell senescence

2018

Yapei Li
Zhouyangfan Peng
Chunle Wang
Le Li
Yiping Leng
Ruifang Chen
Hong Yuan
Shenghua Zhou
Zhen Zhang
Alex F. Chen

This study first provides a novel observation that dsRNA-dependent protein kinase (PKR) mediates palmitate-induced sirtuin 1 inactivation and subsequent human umbilical vein endothelial cell senesc...

Keywords:

Endothelial stem cell
Biochemistry
Protein kinase A
Cell biology
Sirtuin 1
Protein kinase R
Human umbilical vein endothelial cell
Senescence
Diabetes mellitus
Biology
c jun nh2 terminal kinase

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