Comparison of the Inhibitory Effects of Quercetin and Rutin on the Oxidative Modification of LDL induced By Fe(2+)Cu(2+).

Using the oxidative modification of low density lipoprotein (LDL) as a model and the content of thiobabituric acid reactive substances (TBARS) as an index,the inhibitory effects of qnercetin and rntin on oxidative modification of LDL induced by Fe2+ and Cu2+ were compared. The results showed that the rates of oxida tive modification of LDL induced by Fe2+ and Cn2+ were similar in 0.15 mM NaCl (pH7.4). The inhibitory action of quercetin on the oxidative modification of LDL induced by Cu2+ was slightly more effection than in the case of induction by Fe2+, and the action of rutin on the oxidation modification induced by Fe2+ was significantly more effective than in the case of induction by Cu2+.