In Vivo Synergism of Interleukin-3 and Interleukin-6 on Thrombopoiesis in Primates

A substantial amount of information suggests that the process of platelet production is regulated by distinct factors acting at different levels of cellular development [1]. Several cytokines have been shown to stimulate the in vitro growth of bone marrow (BM) megakaryocyte progenitor cells (CFU-Mk) and thereby possess megakaryocyte colony-stimulating activity (MK-CSA) [1].