Coagulación 2009: una visión moderna de la hemostasia

Folllowing vascular injury, blood loss is controlled by the mechanism of hemostasis. In a classic model of coagulation distinct intrinsic and extrinsic pathways converge on a common pathway. This scheme did not take into account the participation of platelets nor other cellular components. The concept has been challenged by a new one in which cells are important participants in the coagulation process. In a modern view, the cell-based model of coagulation actually occurs in an overlapping step-wise process: initiation, amplifi cation and propagation on the surface of activated cells, to produce the burst of thrombin that causes stabilization of the fi brin clot and stop bleeding.