Research progress of early/prefibrotic primary myelofibrosis
2018
Early/prefibrotic primary myelofibrosis (pre-PMF) is an early stage of primary myelofibrosis (PMF). It is a myeloproliferative neoplasms (MPN) with inert clinical manifestations and good prognosis. Diagnosis of pre-PMF mainly depends on bone marrow morphology and secondary clinical criteria. Patients with Pre-PMF have a better prognosis than those of PMF patients. This article reviews the research progress of bone marrow morphology, clinical and laboratory characteristics, gene mutation and load, treatment and prognosis of pre-PMF in order to improve understanding and diagnosis of the disease.
Key words:
Primary myelofibrosis; Megakaryocytes; Gene expression regulation; Drug therapy; Hematopoietic stem cell transplantation; Prognosis
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