Safety of stem cell mobilization in donors with sickle cell trait

High WBC plays a major role in the pathogenesis of many of the complications seen in patients with sickle cell disease (SCD).1 Individuals with Sickle cell trait may develop SCD-related complications in conditions of severe stress.2 G-CSF increases the WBC and may contribute to some of the complications in individuals with sickle cell trait when used in stem cell mobilization. To the best of our knowledge, only one small study3 assessed the safety of the mobilization of stem cells in individuals with sickle cell trait. Herein, we aimed to compare mobilization adverse events between donors with and without sickle cell trait.