Salicylamide inhibitors of influenza virus fusion
2000
Abstract Structural variation of the quinolizidine heterocycle of the influenza fusion inhibitor BMY-27709 was examined by several topological dissections in order to illuminate the critical features of the ring system. This exercise resulted in the identification of a series of synthetically more accessible decahydroquinolines that retained the structural elements of BMY-27709 important for antiviral activity. The 2-methyl- cis -decahydroquinoline 6f was the most potent influenza inhibitor identified that demonstrated an EC 50 of 90 ng/mL in a plaque reduction assay.
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