Bone Graft of the Femoral Neck Marrow Core Drilling Decompression Combined with Transplantation of Autologous Bone Marrow Stem Cells Suspension for the Treatment of StageI, II Osteonecrosis of the Femoral Head

Objective To observe the clinical effect of bone graft of the femoral neck marrow core drilling decompression combined with transplantation of autologous bone marrow stem cells (BMSCs) suspension for the treatment and intervention of stageⅠ, Ⅱosteonecrosis of the femoral head (ONFH). Methods According to the standard of the Association Research Circulation Osseous (ARCO), 24 patients (30 hips) with stageⅠ, ⅡONFH were included in this study. The patients were divided into the experimental group and control group. After autologous BMSCs collection, separation, core decompression in 17 patients with 22 hips who were in the experimental group, first to inject autologous BMSCs suspension into the femoral head lesion, then to mixedly implant autologous BMSCs suspension and bone. 7 patients with 8 hips in the control group were treated with bone graft of the femoral neck marrow core drilling decompression. Results All the patients were followed up for 10 ~ 26 months. The outcomes were determined by changes in Harris hip scores and radiographic progression detected by X-ray and MRI. ①The Harris scores of patients in experimental group increased significantly from (54.82 ± 9.62) to (82.36 ± 8.06) compared with that increased from (55.12 ± 7.95) to (63.84 ± 8.77) in the control group. The rate of excellent and good results was 86.36% in experimental group compared with that of 50.00% in control group. ②In experimental group, 2 cases (2 hips) had aggravated to femoral head collapse as stage Ⅲ, while 3 cases (4 hips) in control group. Conclusion Bone graft of the femoral neck marrow core drilling decompression combined with transplantation of autologous BMSCs suspension for the treatment of stageⅠ, ⅡONFH is a safe and effective method.