Development and validation of naproxen in bulk and tablet dosage form

A simple, accurate, precise and sensitive UV-Spectrophotometric method was developed for the determination of naproxen. The solvent used was ethanol and the wavelength corresponding to maximum absorbance of the drug was found at 242 nm. Beer’s law was obeyed in the concentration range of 10-60 µg/mL with correlation coefficient of 0.9984. The method was validated for several parameters like linearity and range, accuracy, precision and specificity as per International Conference on Harmonization guidelines. The value of the relative standard deviation and %recovery was found to be satisfactory, indicating that the proposed method is precise and accurate and hence can be used for the routine analysis of naproxen.