X-Ray Studies of Horse Liver Alcohol Dehydrogenase

Horse liver alcohol dehydrogenase (LADH) catalyses the oxidation of alcohol to aldehyde when in the presence of the co-factor nicotinamide adenine dinucleotide. It is one of the many NAD-dependent dehydrogenases which are composed of two or four subunits each of molecular weight between 35.000 and 40.000. Of these a low resolution X-ray study has been reported for lactate dehydrogenase (l) and preliminary X-ray data for glyceraldehyde-3-phosphate dehydrogenase (2), soluble malate dehydrogenase (3) and liver alcohol dehydrogenase(4).