Development of the Human Kidney: Immunohistochemical Findings

The development of the human kidney is a complex process that requires interactions among multiple cell types of different embryological origin, including multipotential/stem cells, epithelial and mesenchymal cells: moreover, all these cell types undergo, during fetal kidney development, multiple steps of cellular differentiation, some of which have not well defined and characterized yet. The coordinate development of multiple highly specialized epithelial, vascular, and stromal cell types is a peculiar feature of the kidney architectural and functional complexity.