Isothiazole ketone substituted benzene dicarboxylic acid derivative and usage thereof in preparation of beta-secretase inhibitor

The invention relates to an isothiazole ketone substituted benzene dicarboxylic acid derivative and the usage thereof in preparation of beta-secretase inhibitor. More particularly, the invention relates to a compound in formula I or II, or possible isomer, prodrug, pharmaceutical salt, solvent complex or hydrate, wherein symbols are described in specification. The invention further relates to a preparation method, a pharmaceutical composition containing the compound, and the usage of the compound in the preparation of medicine for treating and/or preventing diseases or symptoms relating to beta-amyloid peptide aggregation or settlement. The compound can be used as the beta-secretase inhibitor.