Fludarabine and melphalan conditioning with tacrolimus as GVHD prophylaxis for allogeneic stem cell transplant recipients is an effective reduced-intensity combination regimen compared to the conventional regimen

Osamu Imataki,Hiroaki Ohnishi,Yumiko Ohbayashi,Akira Kitanaka,Yoshitsugu Kubota,Toshihiko Ishida,Terukazu Tanaka

Fludarabine and melphalan conditioning with tacrolimus as GVHD prophylaxis for allogeneic stem cell transplant recipients is an effective reduced-intensity combination regimen compared to the conventional regimen

2009

Osamu Imataki
Hiroaki Ohnishi
Yumiko Ohbayashi
Akira Kitanaka
Yoshitsugu Kubota
Toshihiko Ishida
Terukazu Tanaka

Background As a reduced-intensity stem-cell transplantation (RIST) regimen, the combination of fludarabine and melphalan (FM) with an appropriate immunosuppressant reduces nonrelapse mortality (NRM).

Keywords:

Regimen
Oncology
Total body irradiation
Stem cell
Graft-versus-host disease
Pathology
Melphalan
Tacrolimus
Transplantation
Internal medicine
Fludarabine
Medicine
reduced intensity
gvhd prophylaxis

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