A phase I clinical study of safingol followed by cisplatin: promising activity in refractory adrenocortical cancer with novel pharmacology

Richard D. Carvajal,Alfred H. Merrill,H. Dials,A. Barbi,G.K. Schwartz

A phase I clinical study of safingol followed by cisplatin: promising activity in refractory adrenocortical cancer with novel pharmacology

2006

Richard D. Carvajal
Alfred H. Merrill
H. Dials
A. Barbi
G.K. Schwartz

13044 Background: Safingol (L-threo-dihydrosphingosine), originally identified as a competitive inhibitor of protein kinase C, has been re-identified as an inhibitor of sphingosine kinase (SK). Inh...

Keywords:

Safingol
Cisplatin
Cancer
Pharmacology
Medicine
Sphingosine kinase
competitive inhibitor
Protein kinase A
Refractory
adrenocortical cancer
clinical study

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations