Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: ‘designer’ changes in Vmax, stability and membrane association

Miles D. Houslay,Grant Scotland,L. Pooley,Sandra Spence,I. Wilkinson,F. McCallum,P. Julien,N.G. Rena,Alison M. Michie,Suat Erdogan,L Zeng,J. C. O'Connell,Edward S. Tobias,I. MacPhee

Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: ‘designer’ changes in Vmax, stability and membrane association

1995

Miles D. Houslay
Grant Scotland
L. Pooley
Sandra Spence
I. Wilkinson
F. McCallum
P. Julien
N.G. Rena
Alison M. Michie
Suat Erdogan
L Zeng
J. C. O'Connell
Edward S. Tobias
I. MacPhee

Abbreviations used: cAMP, cyclic AMP; PKA, cAMP-dependent protein kinase; PDE, phosphodiesterase; Met26-RD1, RD1 lacking the N-terminal 25 amino acids; CAT, chloramphenical acetyltransferase.

Keywords:

Protein kinase A
Biochemistry
Molecular biology
Gene isoform
Membrane
Gene
Biology
Amino acid
Acetyltransferase
Alternative splicing
Phosphodiesterase

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