Changes in immunological parameters in patients with opium abuse receiving ANAR therapy.

We studied the effects of ANAR containing antibodies to morphine in ultralow doses on immunological parameters in patients with opium abuse. Changes in blood content of immunocompetent CD3+, CD16+, and HLA-DR+ cells, lymphocytes carrying receptors for serotonin and dopamine, and humoral immune factors were evaluated. As differentiated from standard preparations, ANAR possessed immunomodulatory properties, increased the content of HLA-DR+ lymphocytes and immunoglobulins in the blood, and normalized the number of CD16+ cells.