The value of combined detection of serum precalcitonin, prealbumin and retinol-binding protein in the early diagnosis of sepsis

Objective To investigate the clinical diagnosis value of serum precalcitonin(PCT) and early predictive significance of prealbumin (PA) and retinol-binding protein (RBP) in liver and renal injury for sepsis in children. Methods One hundred and fifty sepsis children were enrolled from the ward of children in Taizhou Hospital of Zhejiang Province from January 2018 to August 2019. In the same period 150 children with common infection and 150 healthy children who underwent physical examination were included into the study. According to the test, basic data was collected, and biochemical examinations, including the concentrations of the liver function, renal function, PA and RBP were measured. Then the data in the three groups was analyzed. Results The levels of PCT in sepsis group were significantly higher than those in the common infection group and the normal group: (7.02 ± 5.26) μg/L vs. (0.37 ± 0.28), (0.03 ± 0.01) μg/L; the levels of PA and RBP in sepsis group were significantly lower than those of the other two groups: (9.31 ± 4.36) mg/dl vs. (31.05 ± 5.05), (33.56 ± 4.59) mg/dl; (9.26 ± 3.58) mg/L vs. (31.2 ± 5.89), (33.83 ± 6.31) mg/L, and there were significant statistical differences (P 0.05). There were no significant statistical differences in other indicators such as alanine aminotransferase, asparagus cochinchinensis, albumin, urea nitrogen and creatinine (P > 0.05). Conclusions Combined detection of serum PCT, PA and RBP plays an important role in the early diagnosis of children′s sepsis. Key words: Sepsis; Prealbumin; Retinol-binding proteins; Child; Precalcitonin