Transthyretin

1BM7, 1BMZ, 1BZ8, 1BZD, 1BZE, 1DVQ, 1DVS, 1DVT, 1DVU, 1DVX, 1DVY, 1DVZ, 1E3F, 1E4H, 1E5A, 1ETA, 1ETB, 1F41, 1F86, 1FH2, 1FHN, 1G1O, 1GKO, 1ICT, 1III, 1IIK, 1IJN, 1QAB, 1QWH, 1RLB, 1SOK, 1SOQ, 1THA, 1THC, 1TLM, 1TSH, 1TT6, 1TTA, 1TTB, 1TTC, 1TTR, 1TYR, 1TZ8, 1U21, 1X7S, 1X7T, 1Y1D, 1Z7J, 1ZCR, 1ZD6, 2B14, 2B15, 2B16, 2B77, 2B9A, 2F7I, 2F8I, 2FBR, 2FLM, 2G3X, 2G3Z, 2G4E, 2G4G, 2G5U, 2G9K, 2GAB, 2H4E, 2M5N, 2NOY, 2PAB, 2QEL, 2QGB, 2QGC, 2QGD, 2QGE, 2ROX, 2ROY, 2TRH, 2TRY, 2WQA, 3A4D, 3A4E, 3A4F, 3B56, 3BSZ, 3BT0, 3CBR, 3CFM, 3CFN, 3CFQ, 3CFT, 3CN0, 3CN1, 3CN2, 3CN3, 3CN4, 3CXF, 3D7P, 3DGD, 3DID, 3DJR, 3DJS, 3DJT, 3DJZ, 3DK0, 3DK2, 3DO4, 3ESN, 3ESO, 3ESP, 3FC8, 3FCB, 3GLZ, 3GPS, 3GRB, 3GRG, 3GS0, 3GS4, 3GS7, 3HJ0, 3I9A, 3I9I, 3IPB, 3IPE, 3KGS, 3KGT, 3KGU, 3M1O, 3NEO, 3NES, 3NEX, 3NG5, 3OZK, 3OZL, 3SSG, 3TCT, 3TFB, 3U2I, 3U2J, 3W3B, 4ABQ, 4ABU, 4ABV, 4ABW, 4AC2, 4AC4, 4ACT, 4ANK, 4DER, 4DES, 4DET, 4DEU, 4DEW, 4FI6, 4FI7, 4FI8, 4HIQ, 4HIS, 4IIZ, 4IK6, 4IK7, 4IKI, 4IKJ, 4IKK, 4IKL, 5TTR, 3D2T, 3I9P, 3IMR, 3IMS, 3IMT, 3IMU, 3IMV, 3IMW, 3NEE, 3P3R, 3P3S, 3P3T, 3P3U, 4HJS, 4HJT, 4HJU, 4I85, 4I87, 4I89, 4KY2, 4L1S, 4L1T, 4MAS, 4MRB, 4MRC, 4N85, 4N86, 4N87, 4PM1, 4PME, 4PMF, 4PVL, 4PVM, 4PVN, 4PWE, 4PWF, 4PWG, 4PWH, 4PWI, 4PWJ, 4PWK, 4QRF, 4QXV, 4QYA, 4TQ8, 4TQH, 4TQI, 4TQP, 4WNJ, 4WNS, 4WO0, 4YDM, 4YDN, 5BOJ, 4Y9B, 4Y9C, 4Y9E, 4Y9F, 4Y9G, 4TKW, 4TL4, 4TL5, 4TLK, 4TLS, 4TLT, 4TM9, 4TNE, 5AKS, 5AKT, 5AKV, 5AL0, 5AL8, 5CR1, 4TNF, 4TLU, 5AYT, 4TNG, 5EZP, 4D7B, 5A6I, 5E23, 5CNH, 5E4O, 5CN3, 5EN3, 5DWP, 5K1J, 5E4A, 5HJG, 5IHH727622139ENSG00000118271ENSMUSG00000061808P02766P07309NM_000371NM_013697NP_000362NP_038725Transthyretin (TTR or TBPA) is a transport protein in the serum and cerebrospinal fluid that carries the thyroid hormone thyroxine (T4) and retinol-binding protein bound to retinol. This is how transthyretin gained its name: transports thyroxine and retinol. The liver secretes transthyretin into the blood, and the choroid plexus secretes TTR into the cerebrospinal fluid.1bm7: HUMAN TRANSTHYRETIN (PREALBUMIN) COMPLEX WITH FLUFENAMIC ACID (2-3-(TRIFLUOROMETHYL)PHENYL AMINO BENZOIC ACID)1bmz: HUMAN TRANSTHYRETIN (PREALBUMIN)1bz8: TRANSTHYRETIN (DEL VAL122)1bzd: TERTIARY STRUCTURES OF THREE AMYLOIDOGENIC TRANSTHYRETIN VARIANTS AND IMPLICATIONS FOR AMYLOID FIBRIL FORMATION1bze: TERTIARY STRUCTURES OF THREE AMYLOIDOGENIC TRANSTHYRETIN VARIANTS AND IMPLICATIONS FOR AMYLOID FIBRIL FORMATION1dvq: CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN1dvs: CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH RESVERATROL1dvt: CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH FLURBIPROFEN1dvu: CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH DIBENZOFURAN-4,6-DICARBOXYLIC ACID1dvx: CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH DICLOFENAC1dvy: CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH N-(M-TRIFLUOROMETHYLPHENYL) PHENOXAZINE-4,6-DICARBOXYLIC ACID1dvz: CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH O-TRIFLUOROMETHYLPHENYL ANTHRANILIC ACID1e3f: STRUCTURE OF HUMAN TRANSTHYRETIN COMPLEXED WITH BROMOPHENOLS: A NEW MODE OF BINDING1e4h: STRUCTURE OF HUMAN TRANSTHYRETIN COMPLEXED WITH BROMOPHENOLS: A NEW MODE OF BINDING1e5a: STRUCTURE OF HUMAN TRANSTHYRETIN COMPLEXED WITH BROMOPHENOLS: A NEW MODE OF BINDING1eta: THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL 30-->MET VARIANT TO 1.7 ANGSTROMS RESOLUTION1etb: THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL 30-->MET VARIANT TO 1.7 ANGSTROMS RESOLUTION1f41: CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN AT 1.5A RESOLUTION1f86: TRANSTHYRETIN THR119MET PROTEIN STABILISATION1fh2: TRANSTHYRETIN STABILITY AS A KEY FACTOR IN AMYLOIDOGENESIS1fhn: TRANSTHYRETIN STABILITY AS A KEY FACTOR IN AMYLOIDOGENESIS1g1o: CRYSTAL STRUCTURE OF THE HIGHLY AMYLOIDOGENIC TRANSTHYRETIN MUTANT TTR G53S/E54D/L55S1gko: AN ENGINEERED TRANSTHYRETIN MONOMER THAT IS NON-AMYLOIDOGENIC - UNLESS PARTIALLY DENATURED1ict: MONOCLINIC FORM OF HUMAN TRANSTHYRETIN COMPLEXED WITH THYROXINE (T4)1iii: CRYSTAL STRUCTURE OF THE TRANSTHYRETIN MUTANT TTR Y114C-DATA COLLECTED AT ROOM TEMPERATURE1iik: CRYSTAL STRUCTURE OF THE TRANSTHYRETIN MUTANT TTR Y114C-DATA COLLECTED AT CRYO TEMPERATURE1ijn: Crystal structure of the transthyretin mutant TTR C10A/Y114C1qab: The structure of human retinol binding protein with its carrier protein transthyretin reveals interaction with the carboxy terminus of RBP1qwh: a covalent dimer of transthyretin that affects the amyloid pathway1rlb: RETINOL BINDING PROTEIN COMPLEXED WITH TRANSTHYRETIN1sok: Crystal structure of the transthyretin mutant A108Y/L110E solved in space group p212121soq: Crystal structure of the transthyretin mutant A108Y/L110E solved in space group C21tha: MECHANISM OF MOLECULAR RECOGNITION. STRUCTURAL ASPECTS OF 3,3'-DIIODO-L-THYRONINE BINDING TO HUMAN SERUM TRANSTHYRETIN1thc: CRYSTAL STRUCTURE DETERMINATION AT 2.3A OF HUMAN TRANSTHYRETIN-3',5'-DIBROMO-2',4,4',6-TETRA-HYDROXYAURONE COMPLEX1tlm: STRUCTURAL ASPECTS OF INOTROPIC BIPYRIDINE BINDING: CRYSTAL STRUCTURE DETERMINATION TO 1.9 ANGSTROMS OF THE HUMAN SERUM TRANSTHYRETIN-MILRINONE COMPLEX1tsh: TERTIARY STRUCTURES OF THREE AMYLOIDOGENIC TRANSTHYRETIN VARIANTS AND IMPLICATIONS FOR AMYLOID FIBRIL FORMATION1tt6: The orthorhombic crystal structure of transthyretin in complex with diethylstilbestrol1tta: THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL30MET VARIANT TO 1.7 ANGSTROMS RESOLUTION1ttb: THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL30MET VARIANT TO 1.7 ANGSTROMS RESOLUTION1ttc: THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL30MET VARIANT TO 1.7 ANGSTROMS RESOLUTION1ttr: TRANSTHYRETIN-V/122/I CARDIOMYOPATHIC MUTANT1tyr: TRANSTHYRETIN COMPLEX WITH RETINOIC ACID1tz8: The monoclinic crystal structure of transthyretin in complex with diethylstilbestrol1u21: transthyretin with tethered inhibitor on one monomer.1x7s: The X-ray crystallographic structure of the amyloidogenic variant TTR Tyr78Phe1x7t: Structure of TTR R104H: a non-amyloidogenic variant with protective clinical effects1y1d: Crystal structure of transthyretin in complex with iododiflunisal1z7j: Human transthyretin (also called prealbumin) complex with 3, 3',5,5'-tetraiodothyroacetic acid (t4ac)1zcr: Crystal structure of human Transthyretin with bound iodide1zd6: Crystal structure of human transthyretin with bound chloride2b14: The crystal structure of 2,4-dinitrophenol in complex with the amyloidogenic variant Transthyretin Leu 55 Pro2b15: The crystal structure of 2,4-dinitrophenol in complex with human transthyretin2b16: The crystal structure of 2,4-dinitrophenol in complex with the amyloidogenic variant Transthyretin Tyr78Phe2b77: Human transthyretin (TTR) complexed with Diflunisal analogues- TTR.2',4'-DICHLORO-4-HYDROXY-1,1'-BIPHENYL-3-CARBOXYLIC ACID2b9a: Human transthyretin (TTR) complexed with diflunisal analogues- TTR.3',5'-difluorobiphenyl-4-carboxylic acid2f7i: Human transthyretin (TTR) complexed with diflunisal analogues- TTR. 2',6'-Difluorobiphenyl-4-carboxylic Acid2f8i: Human transthyretin (TTR) complexed with Benzoxazole2fbr: Human transthyretin (TTR) complexed with bivalant amyloid inhibitor (4 carbon linker)2flm: Human transthyretin (TTR) complexed with bivalant amyloid inhibitor (6 carbon linker)2g3x: Crystal structure of Transthyretin mutant I84S at acidic pH2g3z: Crystal structure of Transthyretin mutant I84A at low pH2g4e: Crystal structure of transthyretin mutant I84A at neutral pH2g4g: Crystal structure of human transthyretin at pH 4.62g5u: Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4,4'-dihydroxy-3,3',5,5'-tetrachlorobiphenyl2g9k: Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-2',3,3',4',5-Pentachlorobiphenyl2gab: Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-3,3',5,4'-tetrachlorobiphenyl2h4e: Crystal structure of Cys10 sulfonated transthyretin2noy: Crystal structure of transthyretin mutant I84S at PH 7.52pab: STRUCTURE OF PREALBUMIN, SECONDARY, TERTIARY AND QUATERNARY INTERACTIONS DETERMINED BY FOURIER REFINEMENT AT 1.8 ANGSTROMS2rox: TRANSTHYRETIN (ALSO CALLED PREALBUMIN) COMPLEX WITH THYROXINE (T4)2roy: TRANSTHYRETIN (ALSO CALLED PREALBUMIN) COMPLEX WITH 3',5'-DINITRO-N-ACETYL-L-THYRONINE2trh: TERTIARY STRUCTURES OF THREE AMYLOIDOGENIC TRANSTHYRETIN VARIANTS AND IMPLICATIONS FOR AMYLOID FIBRIL FORMATION2try: TERTIARY STRUCTURES OF THREE AMYLOIDOGENIC TRANSTHYRETIN VARIANTS AND IMPLICATIONS FOR AMYLOID FIBRIL FORMATION5ttr: LEU 55 PRO TRANSTHYRETIN CRYSTAL STRUCTURE Transthyretin (TTR or TBPA) is a transport protein in the serum and cerebrospinal fluid that carries the thyroid hormone thyroxine (T4) and retinol-binding protein bound to retinol. This is how transthyretin gained its name: transports thyroxine and retinol. The liver secretes transthyretin into the blood, and the choroid plexus secretes TTR into the cerebrospinal fluid. TTR was originally called prealbumin (or thyroxine-binding prealbumin) because it ran faster than albumin on electrophoresis gels.