Major American dietary patterns are related to risk of age-related macular degeneration (810.2)

Objective: We hypothesized that major American dietary patterns and differences in specific nutrient intakes within the context of the patterns are associated with age-related macular degeneration (AMD) risk. Methods: 8,103 eyes from 4,088 eligible participants were classified into control, early AMD, and advanced AMD. Using 37 food group data collected by a 90-item food frequency questionnaire, two major dietary patterns, prudent and Western patterns, were identified by factor analysis. Results: For early AMD, the multivariate-adjusted odds ratio (OR) comparing the highest to lowest quintile of the prudent pattern score was ORE5P=0.74 (95% confidence interval (CI): 0.59-0.91; Ptrend=0.01), and the OR comparing the highest to lowest quintile of the Western pattern score was ORE5W=1.56 (1.18-2.06; Ptrend=0.01). For advanced AMD, the ORA5P was 0.38 (0.27-0.54; Ptrend<0.0001), and the ORA5W was 3.70 (2.31-5.92; Ptrend<0.0001). Our data also suggested benefit from higher dietary intakes of vitamin C, lutein/z...