Clinical characteristics and virological responses to pegylated interferon plus ribavirin combination therapy in the hepatitis B and C virus coinfected patients

tion, all with p<0.01. In CHB patients, MIF, TGF, IL-17 and ALT levels were positively correlated (r = 0.725, 0.687, 0.831; p<0.01, 0.05, 0.01, respectively), IL-10 and ALT was negatively correlated (r = -0.562, p =<0.05). .Multivariate analysis showed that the levels of increment of MIF, TGFand IL-17 were associated with the increment of HBV DNA load and severity of liver disease. Conclusion: There is amarked correlation between the concentration of MIF, TGFand IL-17 and the severity of liver disease and viral replication. Increased serum levels of MIF, TGFand IL17 correlate positively with the severity of liver disease and active viral replication in chronic HBV infection.