Effet inducteur de la 2-5A-synthétase par des vaccins antirabiques à destinée humaine dans des lymphocytes humains non sensibilisés

Summary The interferon response of non-sensitized human lymphocytes to 3 anti-rabies vaccines and to vesicular stomatitis virus (VSV) in vitro was studied using an assay of interferon-induced 2-5A-synthetase in lymphocyte extracts. Rabies vaccine prepared from foetal bovine kidney cells and a human diploid cell strain led to stimulation of enzymatic activity. The response to the two vaccines and to VSV showed a correlation in the lymphocytes of 72 % of subjects. In contrast, suckling mouse brain vaccine decreased the enzymatic activity, which was lower than the base level in lymphocytes of 67 % of subjects, probably due to an inhibitory substance in the brain from which this vaccine was prepared.