Effect of Tripterygium Glycosides on Levels of Tumor Necrosis Factor-α and Interleukin-8 in Serum of Children with Henoch-Schonlein Purpura Nephritis

Objective To observe the pharmacological effect of tripterygium glycosides treatment on children with Henoch-Schonlein purpura nephritis(HSPN) and the change in serum levels of TNF-α and IL-8. Methods Thirty-eight patients diagnosed as HSPN were randomly divided into a control group(18 patients,oral drug:antiplatelet aggregating,antihistamine,low-molecular-weight heparin sodium,joint prednisone) and a treatment group(20 cases,add tripterygium glcosides 1.5 mg·kg-1·d-1,last for 4 weeks).The effect of drug treatment and the changes in skin purpura,24-hour proteinuria quantity,urinary sediment analysis were observed.The serum levels of TNF-α and IL-8(consisting the before and behind of treatment) were detected by using radio-immunity analysis,moreover,data of the two groups were compared.SPSS 11.5 software was used to analyze the data. Results The total clinical effective rate in treatment group was higher that in the control group(χ2=10.526,P0.05),serum levels of TNF-α and IL-8 in two groups were all decreased,but the levels in treatment group decreased more than that in the control group obviously,and the difference was significant(P0.01). Conclusions The clinical pharmacology effection of tripterygium glycosides treatment on children with HSPN is efficient,and it can suppress the serum levels of TNF-α and IL-8.