2-amino-5,6-difluor-1-(beta-d-ribofuranosyl)-benzimidazole, method for production and antiviral activity in terms of herpes simplex virus type i

FIELD: pharmacology. SUBSTANCE: invention relates to a 2-amino-5,6-difluoro-1-(beta-D-ribofuranosyl)-benzimidazole of formula (I) suitable for treatment of herpes, and a method for its preparation that can be used in the pharmaceutical industry: (I). The proposed method involves ortho-phenylenediamine condensing with bromocyanide, followed by bromohydrate removal with sodium carbonate and a reaction of obtained base transribosylation with uridine in the presence of catalytic amounts of uridine phosphorylase and purine nucleoside phosphorylase. EFFECT: new effective anti-herpes virus compound is proposed, including that against variants of the virus resistant to the action of basic antiherpetic drugs, as well as a new effective method for obtaining. 3 cl, 3 ex, 4 dwg