Release of alpha-tocopherol from antioxidative low-density polyethylene film into fatty food simulant: influence of complexation in beta-cyclodextrin.
2006
The release of alpha-tocopherol from two formulations (with and without complexation with beta-cyclodextrin) of low-density polyethylene (LDPE) film was examined. Specific migration studies were performed at 7.0 ± 0.5°C using plastic bags filled with 95% ethanol as a fatty food simulant. The amount of complexed and free (non-complexed) alpha-tocopherol migrating into the food simulant was followed by high-performance liquid chromatography (HPLC). It was concluded that complexation with beta-cyclodextrin had a significant effect on the release rate of the antioxidant. Using a mathematical model for the description of the migration, a decrease in diffusion coefficient (D) of one order of magnitude was calculated in the case of complexed alpha-tocopherol compared with the free form. Total migration of alpha-tocopherol from both films was observed, meaning that the partition coefficient of tocopherol was not influenced by incorporation with cyclodextrin. Thus, complexation might be the key to a long-lasting a...
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