Synthesis, properties, and electron impact fragmentation of fluorinated 1-arylbiguanides

A number of 1-aryl-, 1,5-diaryl-, and 1-aryl-5-alkyl-biguanides bearing fluoro- and trifluoromethyl substituents on the aromatic ring have been synthesised; their chemical properties are described. Electron impact fragmentation in various 1-arylbiguanides has been investigated. Several of the compounds reported show anti-inflammatory, anorexigenic, and antimicrobial activities.