CSF Dynamics and Ventricular Size in Experimental Sagittal Sinus Occlusion Models

The relationship of increased cerebral venous pressure to ventricular enlargement and the role of a distensible skull have remained controversial (Bering and Salibi 1959, Guthrie et al. 1970). Clinically, it is well known that increased intracranial venous pressure may lead to hydrocephalus in younger infants and to benign intracranial hypertension in older patients (Rosman et al. 1978). However, there have been very few reports on changes in CSF dynamics and ventricular size after sagittal sinus occlusion because a good experimental model of sagittal sinus occlusion has not been available. The aim of this study is to evaluate the changes in CSF dynamics and ventricular size and to define the role of craniectomy in a new model of sagittal sinus occlusion.