The Procoagulant Effect of Thrombin on Fibrin(ogen)-Bound Platelets

Marijke W. Sanders,Cécile M.A. Nieuwenhuys,Marion A.H. Feijge,Martin B. Rook,Suzette Béguin,Johan W. M. Heemskerk

The Procoagulant Effect of Thrombin on Fibrin(ogen)-Bound Platelets

1998

Marijke W. Sanders
Cécile M.A. Nieuwenhuys
Marion A.H. Feijge
Martin B. Rook
Suzette Béguin
Johan W. M. Heemskerk

In a final stage of activation, platelets become procoagulant because of the appearance of phosphatidylserine (PS) at the membrane outer surface. This PS exposure requires a rise in cytosolic [Ca

Keywords:

Biochemistry
Thrombin
Fibrin
Fibrinogen
Phosphatidylserine
Membrane
Platelet
Chemistry
In vitro
Cytosol

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