Practical and versatile oxidation of alcohol using novel Na2WO4–H2O2 system under neutral conditions

Abstract This paper presents a novel Na 2 WO 4 –H 2 O 2 oxidation system. The oxidation of alcohol to ketone or aldehyde was carried out by using N , N -dimethylacetamide, hydrogen peroxide, and a catalytic amount of disodium tungstate dihydrate under neutral conditions. This method is very simple, practical for large-scale manufacturing, and applicable to a variety of substrates including an acid-sensitive substrate. Disodium tetraperoxotungstate dihydrate (Na 2 [W(O 2 ) 4 ]·2H 2 O) was isolated from a mixture of N , N -dimethylacetamide, hydrogen peroxide, and disodium tungstate dihydrate, and a proposal reaction mechanism is discussed in this paper.